The Gunners returned to winning ways last weekend with a 3-0 Premier League win over Nottingham Forest at the Emirates Stadium.
The focus will now shift to the league phase of the Champions League where Arsenal are two points adrift of the automatic last 16 places.
The London giants face a tricky challenge against an in-form Sporting CP outfit, but manager Mikel Arteta will want nothing less than a victory.
David Raya has been an undisputed starter in the Premier League and Champions League games. He has been brilliant with spectacular saves and recently kept his first clean sheet since mid-October. The Spaniard is guaranteed to start between the sticks.
In front of him, it should be the same backline from the Forest win. Jurrien Timber and Riccardo Calafiori will start in the right and left-back positions with William Saliba accompanying Gabriel Magalhaes in central defence as usual.
Jorginho had an eventful opening half on Saturday. The Italian impressed with his distribution, but was substituted at the break due to a booking. He could drop to the bench tonight alongside Mikel Merino.
Merino caught the eye with his late surging runs into the box. The duo are likely to be replaced with Thomas Partey and Declan Rice respectively. Rice was an unused substitute last weekend. He has been nursing a broken toe in recent weeks.
