Ahead of the game, manager Mikel Arteta will be forced into two changes with Gabriel Martinelli and Kai Havertz on the sidelines with injuries.
Formation: 4-3-3
Predicted Line-up:
David Raya has been ever-present in goal for the Gunners in the Premier League. He will be aiming for a clean sheet from the Midlands trip.
In front of him, it should be the same backline from recent games. Ben White is fit again after knee surgery, but he could be eased back into first-team action.
Jurrien Timber is poised to start at right-back. William Saliba and Gabriel Magalhaes are likewise guaranteed their places in central defence.
Myles Lewis-Skelly should continue at left-back ahead of Riccardo Calafiori amid his superb league form. He scored a brilliant maiden goal in the 5-1 win over Manchester City.
In the centre of the park, no changes are on the cards. Thomas Partey is best suited for the no.6 role. Declan Rice has excelled from a central attacking role. He is expected to start there alongside captain Martin Odegaard.
In attack, Arteta has no room to rotate with Martinelli, Havertz, Bukayo Saka and Gabriel Jesus injured. Ethan Nwaneri, Leandro Trossard and Raheem Sterling are guaranteed to start against the Foxes.
Trossard could operate as the main striker with Sterling in his preferred left-wing position. Nwaneri, described as a ‘big talent‘ by Arteta, looks poised to feature on the right wing.
The youngster has seven goals in his breakthrough campaign. He has netted two stunning long-range goals this year and will be aiming to enhance his reputation with another top display.
Predicted Arsenal line-up (4-3-3) vs Leicester City: Raya; Timber, Saliba, Gabriel, Lewis-Skelly; Partey, Odegaard, Rice; Nwaneri, Trossard, Sterling.