The Red Devils head Stateside on Wednesday, flying to Los Angeles as they prepare to face pre-season clashes against Arsenal, Real Betis and Liverpool.
However, defender Tyrell Malacia will miss the trip, while several key first-team players including new signing Joshua Zirkzee are also absent.
Malacia did not make an appearance for United last season as he recovered from knee surgery.
The 24-year-old is back in individual training this summer but was not ready to feature in United’s 2-0 friendly win over Scottish giants Rangers last weekend.
And the Red Devils have confirmed that the Dutchman will not be part of the 29-man group as he continues to build up his fitness.
Malacia joins the likes of Bruno Fernandes, Alejandro Garnacho, Kobbie Mainoo, Lisandro Martinez, Facundo Pellistri, Luke Shaw, Diogo Dalot and Altay Bayindir in missing out as they are all on holiday after playing at Euro 2024 or at the Copa America and will return to training at Carrington instead.
Zirkzee will also be absent as he continues on his break after completing a £36.5m move to United earlier this month. He will also return to Carrington.